Complete Walkthrough For Chapter Thirteen In Resident Evil 4 Remake

Start your infiltration of the Island off right with this guide for Resident Evil 4 Remake!

The Island, the home of the Los Illuminados cult for hundreds of years, is the final area in Resident Evil 4 Remake. The Ganados here have military-grade equipment and their usual ferocity, and you'll also have to face some of the game's most terrifying monsters. In other words, take every advantage that you can get!

Related: Resident Evil 4 Remake: Chapter Twelve Walkthrough

Adapting to the new challenges of the Island is critical to survival, so you'll have to learn as you go when surprises pop up. Thankfully, this guide has full information on the area's first chapter. Read on to find everything you need to know as you search for Luis's lab... and Ashley.

This guide contains spoilers.

Start by climbing the ledges to the left. The island facility will quickly come into view. Use your binoculars along the path to spot Ashley, then keep going. Ahead, you'll see that the path to the facility is blocked by a security laser. Ignore it for now and take the right-hand tunnel.

Turn right at the fork to find some barrels and lore, then turn around and take the other path. Visit the Merchant in his alcove, then follow the side tunnel to reach the back of the security laser and disable it.

Go past the laser and carefully move forward toward the building in front of you. Be sure not to stray too far to the left, or you'll trigger another laser. One way or another, you'll be spotted, triggering a fight.

The main threat during this battle is the mini-gunner. He'll try to close in and corner you; use this as an opportunity to hit him with the shotgun. While his gun is revved up, you can cause it to explode by shooting it, but this will only damage the gunner, not kill him.

Inside the building is a ladder leading to the roof; this is the best place to make your stand, though you'll need to quickly kill the crossbowmen on the other rooftops.

When things quiet down a bit, rotate the laser to give yourself a route across the path, through the window of the next building over. Be sure to pick up the Red Herb just outside the window!

The door to the facility is overseen by a turret, so walk along the cliff edge on the left to reach the rear of the turret and disable it. Return to the first building and go through the rear exit to get past the laser's new position and reach the doors.

Inside, there are enemies around nearly every corner, so stay on your toes. Some can be eliminated quietly, but for the most part you'll be fighting face-to-face. Follow the path until you come to a ladder, and climb it. You'll find yourself back outside.

When you come to a bridge, run across it without stopping. If you're quick, you can get a stealth kill from the front on the Ganado coming from the other side before the game recognizes that he's seen you!

Quietly take out the Ganado patrolling the ledge to the left; you can catch him from behind while he's looking over the cliffs. Climb through the window on the right to get the drop on the enemy inside, then proceed down the tunnel to the right to stealthily kill another.

Exploring the rest of the tunnels yields a Yellow Herb and a Golden Lynx, which is behind a wall of rubble that you can clear by shooting a red barrel. By the time you return, a trio of Ganados will have arrived in the building.

These enemies have bulletproof shields. The best way to deal with them is to shoot the lantern on the ceiling in the main room, setting the group on fire.

Leave the building and continue along the path. When the Ganado with the rocket launcher appears, take cover behind the stone wall to your left. Thin out the oncoming enemies from here before trying to cross the launcher's kill-zone.

Take the caverns to the left to ascend to the rocket launcher's ledge. Stay in the tunnel to remain safe from the rockets while eliminating the last of his support, then take out the launcher himself. He can take a lot of damage, so stunning him with a Flash Grenade then following up with a knife finisher is a good way of dealing with him.

When the area is clear, loot any items dropped by the Ganados and go through the doors on the far end.

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Wait at the end of the tunnel before entering the chamber ahead; if you're confident in your sniper skills, you can eliminate the rocket launcher before triggering the fight. He usually spawns a Plaga, so be ready!

Once the enemies below are dealt with, open the chest near the tractor-trailer and shoot the Clockwork Castellan under the truck. Go back up the stairs and loop around the building to find a side door.

The door is booby-trapped; you'll hear the beeping of a bomb as you approach. You'll see the device if you look to the lower left of the door; disable it, then enter.

Climb the ladder on the left and fight your way along the gantry to the surveillance room. Operate the console to the door below, then return to the building entrance. Watch out for the tripwire outside the surveillance room door; if you take the stairs you'll have to deal with it.

Take the Velvet Blue from the briefcase in the middle of the room, then go through the unlocked door with the Los Illuminados emblem on it. In the next room, you'll hear a Ganado and a Brute on the left; take the opportunity to put some damage on them before they notice you.

If you have enough Durability left on your knife, rush the Ganado immediately. If you get a stealth kill, there's a chance you can sneak up on the Brute before he turns around and finish him off in one shot!

After the fight, take the gem dropped by the Brute and climb the ladder ahead and to the right. Check both ends of the platform for items, then open the door in the corner.

When you enter the next room, there's a Ganado in the shadows to the right who will throw a hatchet at you if you aren't careful. Clear the room and proceed down the hall. You'll find long and twisting corridors leading through the kitchens. Be ready for a jump scare! When the flaming Ganado appears, turn left to find the Merchant. Save at the typewriter and go through the door to the left of the desk.

Repair your knife before continuing - you'll need it!

The door in front of you in the next room is locked, so take the stairs and follow the corridor. The doors are all locked along the way, so there's only one path. At the end of the hall, read the note about keycard clearance and pull the switch on the left-hand wall.

Retrace your steps until you see a monitor that wasn't lit before. Use it to power the door to the left; you need to rotate the circuits so that all three lightning bolt symbols are illuminated. Press left and right to change which set of circuits you're adjusting; when the board is properly calibrated, move the switch all the way to the right to activate the power. Use the following chart to quickly complete the puzzle

Circuit Number

Number of Times to Rotate

1

3

2

2

3

2

Before you enter the door, check the room to the left. There's a First Aid Spray on the desk inside, plus a gem and ammo in the glass case.

Take the keycard in the far right-hand corner of the room beyond the door, then leave the room. As you approach the door to the Dissection Lab, you'll be attacked by a Regenerador. This monster can't be killed with the equipment you have, so evade it for now. Use your knife to quickly break the Regenerador's grabs.

Return to the room where you turned the power on and switch it to the Freezer area. Follow the lights if you get lost. Run to the Freezer and use the keycard to enter. Put the keycard in the overwrite machine at the far end; another Regenerador will appear. Keep it at bay until the overwrite finishes and retrieve the keycard.

Optionally, you can use the power calibration panel in the freezer to open the side door and get the LE-5 Submachine Gun. It can be equipped with a scope, making it a versatile part of your arsenal. The calibration settings are:

Circuit Number

Number of Times to Rotate

1

3

2

1

3

3

4

3

Don't return to the power room; switching the power will deactivate the next lock. Instead, turn right out of the Freezer corridor and use the keycard to unlock the door at the bottom of the stairs.

Keep moving until you see another set of stairs beyond; until that point, the Regeneradors will continue to follow you. Kill the three Ganados on the lower level and get the Yellow Herb under the stairs, then proceed.

In the corridor outside the Incubation Lab, check along the left side for Rifle Ammo that will be indispensable in destroying the Regeneradors. Enter the lab and cross to the other side, picking up the Hand Grenade in the center of the room as you pass.

In the back room of the lab, take the Biosensor Scope from the desk and attach it to your rifle. This will allow you to see the Plaga parasites inside Regeneradors; destroying all the parasites will kill the monster. One of the Regeneradors in the tanks has the wrench that you need to open the overwrite terminal; use the Biosensor Scope to see which one has the tool and kill it. The other Regeneradors have gems, including the ones you fled from upstairs; hunting them is a good way to get some extra cash!

If you're having trouble with the Regeneradors in the upstairs hallway, there's an exploit that you can use to easily defeat them. Open the keycard door and lure them through it. When you start going down the stairs, the Regeneradors will automatically turn to leave. Take the opportunity to shoot them in the back, and then start down the stairs again to prevent their counterattack!

Take the Green Herb and the Rifle Ammo on the side table in the lab, then use the wrench to open the overwrite panel and insert the keycard.

You don't have to use the weapon that has the Biosensor Scope to kill the Regeneradors; once you know where the parasites are, you can shoot them out with any weapon you like.

While the keycard is processing, a group of Ganados will enter the lab. Several of them carry dynamite, so if you're quick you can detonate them to quickly thin out the group. Wait by the terminal for the keycard to finish, then grab it and escape through the gate to the right of the lab entrance. The corridor will take you back to the holding cell, where you can use your upgraded keycard to rescue Ashley and end the chapter.

Next: Resident Evil: Unresolved Mysteries In The Series

Matt Arnold is an actor and writer based in New York. A lifelong gamer, he draws on a decade of experience in the tabletop industry. Support your local game store!